Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases (2023)

Senghore, T., Li, Y-F., Sung, F-C., Tsai, M-H., Hua, C-H., Liu, C-S., Hung, M-F.(2018).Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases.cancer research,38(7), 4021-4026.https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049776963&doi=10.21873%2fantacanres.12690&partnerID=40&md5=eab0fb0833f9d8a61115903042d32119

Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases./ Senghor, T.; Lee, Y.-F.; Canted, F.-C. und andere

Em:cancer research, Bd. 38, Nr. 7, 2018, p. 4021-4026.

search result:contribution to the magazine›Article›Peer-Review

Senghore, T, Li, Y-F, Sung, F-C, Tsai, M-H, Hua, CH, Liu, C-S, Hung, M-F2018, 'Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases',cancer research, Bd. 38, Nr. 7, p. 4021-4026. <https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049776963&doi=10.21873%2fantacanres.12690&partnerID=40&md5=eab0fb0833f9d8a61115903042d32119>

Senghore T, Li Y-F, Sung F-C, Tsai M-H, Hua C-H, Liu C-S et al.Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases.cancer research. 2018;38(7):4021-4026.

Senghore, T.; Li, Y.-F. ; Sung, F.-C. and walk /Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases. Em:cancer research. 2018; Bd. 38, Nr. 7. S. 4021-4026.

@artículo{edb96feb471a469abc018cd213acbfb5,

title = "Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases",

abstract="Aim: The study aimed to investigate the role of two methylenetetrahydrofolate reductase (MTHFR) polymorphisms, C677T and A1298C, in the risk of potential oral malignancy (PMOD). Materials and methods: Genotypes of MTHFR polymorphisms C677T and A1298C were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls, 95% confidence interval (CI) = 0.44-0.86] 1298A haplotype was associated with a reduced risk of PMOD (OR = 0.56, 95% CI = 0.40-0.80) Lifestyle changes: Our results suggest that the MTHFR C677T genotype or haplotype carrying the T allele increases the risk of premenstrual syndromes ( PMOD). However, these observations require further confirmation using larger samples.{\textcopyright} 2018 International Institute for Cancer Research. All rights reserved.",

keywords = "Genetic polymorphism, methylenetetrahydrofolate reductase, oral malignancies, Taiwan, 5,10 methylenetetrahydrofolate reductase (FADH2), genomic DNA, methylenetetrahydrofolate reductase (NADPH2), adult, alcohol use, allele, article, carcinogenesis, smoking, oral carcinoma study, comparative controlled study , genetic association, genotype, haplotype, lifestyle, primary clinical study, male, molecular pathology, potentially malignant oral disorder, priority diary, procedure, risk reduction, single nucleotide polymorphism, case-control study, genetic predisposition , genetics, middle age, oral tumor, polymerase chain reaction , restriction fragment length polymorphism, adult, alleles, case-control studies, genetic predisposition to disease, genotype, haplotypes, human, male, methylenetetrahydrofolate reductase (NADPH2), middle-aged, oral neoplasms, polymerase chain reaction, polymorphism, restriction fragment length, polymorphism, single nucleotide, genetic Polymorphism, Methylenetetrahydrofolate Reductase, Oral Potential Malignancies, Taiwan ",

author = "T. Senghore and Y.-F. Li and F.-C. Sung and M.-H. Tsai and C.-H. Hua and C.-S. Liu and M.-F. Hung and C .-C. Sí",

note="Export Date: October 18, 2018 CODEN: ANTRD Address: Yeh, C.-C.; School of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taiwan; Address: ccyeh@tmu.edu . tw." Spec/CAS: 5.10 Methylenetetrahydrofolate reductase (FADH2), 9028-69-7, N., Global Epidemiology of Head and Neck Cancers: An Ongoing Challenge (2016) Oncology, 91(1), S. .-W., You, S .-L., Chen, C.-J., Lai, M.S., Incidence and Survival of Adult Cancer Patients in Taiwan, 2002-2012 (2016) J Formosan Med Assoc, 115 (12), p. 13, Oral Pathol Med, 46(10), pp. 1040-1045; Lyu MY, Guo YS, Li S, Yang D, Hua H. Characterization of malignant transformation of oral leukoplakia in a Chinese population (2017) Int Dent J, 67(4), p ... 101-111. 252-259; Paulino, Y.C., Hurwitz, E.L., Warnakulasuriya, S., Gatewood, R.R. , Pierson, KD, Tenorio, LF, Novotny, R, Badowski, G. Screening for potentially malignant oral disease in areca (betel) nut chewers in Guam and Saipan (2014) BMC Oral Health, 14, p. 151; Fenech, M., The role of folic acid and vitamin B12 in the genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Miri-Moghaddam E, Saravani S, Garme Y, Khosravi A, Bazi A, Motazedian J, Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in southeastern Iran. J Oral Pathol Med, 45(2), pp. 2016-2 96-100; Weisberg I, Tran P, Christensen B, Sibani S, Rozen R, Mol Genet Metab, 64(3), pp. 101-1169-172; Fenech, M., The role of folic acid and vitamin B12 in the genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Frostst, P., Blom, H.J. , Milos R, Goyette P, Sheppard CA. , Mateus RG, Boers GJ, Rozen R A Candidate Genetic Risk Factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase (1995) Nat Genes, 10(1), pp. 107-111. 111-113; NM Van Der Put, F Gabreels, EM Stevens, JA Smeitink, FJ Trijbels, TK Eskes, LP Van Den Heuvel, HJ Blom (1998) Am. J. Hum Genet, 62(5), pp. 1044-1051; Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking, metastasis and oral cancer in Taiwan (2011).) Anticancer Res, 31(6), pp. 2395-2399; Warnakulasuriya, S., Johnson, N.W. , Van Der Waal, I., Nomenclature and Classification of Potentially Malignant Diseases of the Oral Mucosa (2007) J Oral Pathol Med, 36(10), pp. 575-580; Lievers, K.J., Boers, G.H., Verhoef, P., Den Heijer, M., Kluijtmans, L.A. , Van Der Put , N.M. , Trijbels, FJ, Blom, HJ. Its relationship to MTHFR enzyme activity, homocysteine ​​and cardiovascular disease risk (2001) J Mol Med, 79(9), pp. 101-111. 522-528; Guo S, Jiang X, Chen X, Chen L, Li X, Jia Y The Protective Effect of Methylenetetrahydrofolate Reductase Polymorphism C677T against Prostate Cancer Risk: Evidence from 23 Case-Control Studies (2015) Gene, 565 (1), pp. 565–565. 90-95; Son KJ, Croxford R, Yates Z, Lucock M, Kim YI. , Effect of the C677T methylenetetrahydrofolate reductase polymorphism on the chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate (2004) J Natl Cancer Inst, 96(2), pp. 134-144; Jia J, Ma Z, Wu S Positive Association between the MTHFR C677T polymorphism and oral cancer risk: a meta-analysis (2014) Tumor Biol, 35(5), pp. 107-111. 4943-4948; Barbosa A, Dos Santos M, De Podesta JR. , Gouvea , S.A. , von Zeidler, S.V. , Louro, I.D., De Cordeiro-Silva, M.F. , Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta synthase in oral cancer – A case-control study in Southeastern Brazil (2016) Braz J Otorhinolaryngology, 82(5), pp. 107-111. 558-566; Chen Z, Karaplis AC. , Ackermann, S.L. , Pogribny, I.P. , Melnyk, S., Lussier-Cacan, S., Chen, MF. , Rozen, R. with Neuropathology and Fat Deposition in the Aorta (2001) Hum Mol Genet, 10(5), pp. 433-443; Liu C.S., Tsai C.W., Hsia TC, Wang R.F. , Liu, C.J., Hang, L.W., Chiang, S.Y. , Bau, D. T., Interaction of methylenetetrahydrofolate reductase genotype and smoking in Taiwanese patients with lung cancer (2009) Cancer Genomics Proteomics, 6(6), pp. 107-114. 325-329; Chen J, Ma J, Stampfer MJ, Palomeque C, Selhub J, Hunter DJ Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in the human methylenetetrahydrofolate reductase gene and their reviews for risk of colorectal cancer (2002) Pharmacogenetics, 12(4), pp. 101-111. 339-342; [PMC-free article] [PubMed] Yang, C.X. , Matsuo , K , Ito , M , Shinoda , M , Hatooka , S , Hirose , K , Wakai , K , Tajima , K , Gene-environment interactions between alcohol consumption and the effects of the MTHFR C677T polymorphism on the risk of esophageal cancer: results of a case-control study in Japan (2005) Carcinogenesis, 26(7), pp. 107-111. 1285-1290; Interaction of MTHFR C677T polymorphism with excessive alcohol consumption increases risk of head and neck cancer (2015) Sci Rep, 5, p. 10671; Nazki, FH, Sameer, AS, Ganaie, BA, Folate: Metabolism, Genes, Polymorphisms and the Associated Diseases (2014) Gene, 533(1), pp. 11-20",

again="2018",

language = "English",

volume = "38",

pages="4021--4026",

Journal = "Cancer Research",

issn = "0250-7005",

Publisher = "International Institute for Cancer Research",

number = "7",

}

YOU - DIA

T1 - Associations between MTHFR polymorphisms and the risk of potentially malignant oral diseases

AU-Senghore, T.

I - Li, Y.-F.

AU - Cantado, F.-C.

AU - Tsai, M.-H.

AU - Hua, C.-H.

AU - Liu, C.-S.

AU - Colgado, M.-F.

AU - Sim, C.-C.

N1 - Export Date: October 18, 2018 CODEN: ANTRD Keywords: Yeh, C.-C.; School of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taiwan; Email address: ccyeh@tmu.edu.tw CAS/CAS: 5.10 methylenetetrahydrofolate reductase (FADH2), 9028-69-7; methylenetetrahydrofolate reductase (NADPH2), 71822-25-8; Methylenetetrahydrofolate reductase (NADPH2) inhibitors: Gupta, B., Johnson, N.W., Kumar, N., Global Epidemiology of Head and Neck Cancers: An Ongoing Challenge (2016) Oncology, 91(1), pp. 101-116. 13-23; Chiang, C.-J. , Lo , W.-C. , Yang , Y.-W. , you , S.-L. , Chen , C.-J. , Lai, M.S., Incidence and Survival of Adult Cancer Patients in Taiwan, 2002–2012 (2016) J Formosan Med Assoc, 115(12), p. 13; Yang, P.Y., Chen, Y.T., Wang, Y.H., Su, N.Y. , Yu, H.C. , Chang , Y.C. , J Oral Pathol Med, 46(10), pp. 101-1 1040-1045; Lyu MY , Guo YS , Li S , Yang D , Hua H , Hospital-clinical and epidemiological characterization of malignant transformation of oral leukoplakia in a Chinese population (2017) Int Dent J, 67 (2017), 4 ), pp. 252-259; Paulino, Y.C., Hurwitz, E.L., Warnakulasuriya, S., Gatewood, R.R. , Pierson, KD, Tenorio, LF, Novotny, R, Badowski, G. Screening for potentially malignant oral disease in areca (betel) nut chewers in Guam and Saipan (2014) BMC Oral Health, 14, p. 151; Fenech, M., The role of folic acid and vitamin B12 in the genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Miri-Moghaddam E, Saravani S, Garme Y, Khosravi A, Bazi A, Motazedian J, Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in southeastern Iran. J Oral Pathol Med, 45(2), pp. 2016-2 96-100; Weisberg I, Tran P, Christensen B, Sibani S, Rozen R, Mol Genet Metab, 64(3), pp. 101-1169-172; Fenech, M., The role of folic acid and vitamin B12 in the genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Frostst, P., Blom, H.J. , Milos R, Goyette P, Sheppard CA. , Mateus RG, Boers GJ, Rozen R A Candidate Genetic Risk Factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase (1995) Nat Genes, 10(1), pp. 107-111. 111-113; NM Van Der Put, F Gabreels, EM Stevens, JA Smeitink, FJ Trijbels, TK Eskes, LP Van Den Heuvel, HJ Blom (1998) Am. J. Hum Genet, 62(5), pp. 1044-1051; Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking, metastasis and oral cancer in Taiwan (2011).) Anticancer Res, 31(6), pp. 2395-2399; Warnakulasuriya, S., Johnson, N.W. , Van Der Waal, I., Nomenclature and Classification of Potentially Malignant Diseases of the Oral Mucosa (2007) J Oral Pathol Med, 36(10), pp. 575-580; Lievers, K.J., Boers, G.H., Verhoef, P., Den Heijer, M., Kluijtmans, L.A. , Van Der Put , N.M. , Trijbels, FJ, Blom, HJ. Its relationship to MTHFR enzyme activity, homocysteine ​​and cardiovascular disease risk (2001) J Mol Med, 79(9), pp. 101-111. 522-528; Guo S, Jiang X, Chen X, Chen L, Li X, Jia Y The Protective Effect of Methylenetetrahydrofolate Reductase Polymorphism C677T against Prostate Cancer Risk: Evidence from 23 Case-Control Studies (2015) Gene, 565 (1), pp. 565–565. 90-95; Son KJ, Croxford R, Yates Z, Lucock M, Kim YI. , Effect of the C677T methylenetetrahydrofolate reductase polymorphism on the chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate (2004) J Natl Cancer Inst, 96(2), pp. 134-144; Jia J, Ma Z, Wu S Positive Association between the MTHFR C677T polymorphism and oral cancer risk: a meta-analysis (2014) Tumor Biol, 35(5), pp. 107-111. 4943-4948; Barbosa A, Dos Santos M, De Podesta JR. , Gouvea , S.A. , von Zeidler, S.V. , Louro, I.D., De Cordeiro-Silva, M.F. , Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta synthase in oral cancer – A case-control study in Southeastern Brazil (2016) Braz J Otorhinolaryngology, 82(5), pp. 107-111. 558-566; Chen Z, Karaplis AC. , Ackermann, S.L. , Pogribny, I.P. , Melnyk, S., Lussier-Cacan, S., Chen, MF. , Rozen, R. with Neuropathology and Fat Deposition in the Aorta (2001) Hum Mol Genet, 10(5), pp. 433-443; Liu C.S., Tsai C.W., Hsia TC, Wang R.F. , Liu, C.J., Hang, L.W., Chiang, S.Y. , Bau, D. T., Interaction of methylenetetrahydrofolate reductase genotype and smoking in Taiwanese patients with lung cancer (2009) Cancer Genomics Proteomics, 6(6), pp. 107-114. 325-329; Chen J, Ma J, Stampfer MJ, Palomeque C, Selhub J, Hunter DJ Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in the human methylenetetrahydrofolate reductase gene and their reviews for risk of colorectal cancer (2002) Pharmacogenetics, 12(4), pp. 101-111. 339-342; [PMC-free article] [PubMed] Yang, C.X. , Matsuo , K , Ito , M , Shinoda , M , Hatooka , S , Hirose , K , Wakai , K , Tajima , K , Gene-environment interactions between alcohol consumption and the effects of the MTHFR C677T polymorphism on the risk of esophageal cancer: results of a case-control study in Japan (2005) Carcinogenesis, 26(7), pp. 107-111. 1285-1290; Interaction of MTHFR C677T polymorphism with excessive alcohol consumption increases risk of head and neck cancer (2015) Sci Rep, 5, p. 10671; Nazki, FH, Sameer, AS, Ganaie, BA, Folate: Metabolism, Genes, Polymorphisms and the Associated Diseases (2014) Gene, 533(1), pp. 11-2

Fiscal year - 2018

Again 1 - 2018

N2 - Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potential oral malignancy (PMOD). Materials and Methods: The MTHFR C677T and A1298C polymorphism genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls. Results: Genotypes carrying the C677T T allele were significantly associated with a reduced risk of PMOD [odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.44-0.86]. Haplotype analysis also showed that the 677T/1298A haplotype was associated with a lower risk of PMOD (OR=0.56, 95% CI=0.40-0.80). No significant interactions between MTHFR polymorphisms and lifestyle factors were observed. Conclusion: Our results suggest that the MTHFR C677T genotype or haplotype carrying the T allele may reduce PMOD risk. However, these observations require further confirmation using larger samples. © 2018 International Institute for Research on Cancer. All rights reserved.

AB - Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potential oral malignancy (PMOD). Materials and Methods: The MTHFR C677T and A1298C polymorphism genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls. Results: Genotypes carrying the C677T T allele were significantly associated with a reduced risk of PMOD [odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.44-0.86]. Haplotype analysis also showed that the 677T/1298A haplotype was associated with a lower risk of PMOD (OR=0.56, 95% CI=0.40-0.80). No significant interactions between MTHFR polymorphisms and lifestyle factors were observed. Conclusion: Our results suggest that the MTHFR C677T genotype or haplotype carrying the T allele may reduce PMOD risk. However, these observations require further confirmation using larger samples. © 2018 International Institute for Research on Cancer. All rights reserved.

KW - Genetic Polymorphism

KW - Methylentetrahydrofolat-Reduktase

KW - Potentially malignant oral diseases

KW-Taiwan

KW - 5.10 Methylentetrahydrofolat-Reduktase (FADH2)

KW - genomische DNA

KW - Methylenetetrahydrofolate-Reductase (NADPH2)

KW - adult

KW - alcohol consumption

KW - Sprache

KW - Article

KW - carcinogenesis

KW - smoke cigarettes

KW - comparative study

KW - controlled study

KW - genetic association

KW - genotype

KW - Haplotype

KW - Man

KW - Lifestyle

KW - main clinical study

KW-small

KW - Molecular Pathology

KW - carcinoma of the mouth

KW - potentially malignant oral disease

KW - daily priority

KW - procedure

KW - Risk Reduction

KW - single nucleotide polymorphism

KW - case control study

KW - genetic predisposition

KW - Genetics

KW - middle age

KW - Buccal Tumor

KW - polymerase chain reaction

KW - Restriction fragment length polymorphism

KW - adult

KW - Alelos

KW - case control studies

KW - Genetic predisposition to disease

KW - genotype

KW - Haplotype

KW - people

KW - Male

KW - Methylenetetrahydrofolate-Reductase (NADPH2)

KW - Middle Ages

KW - Oral neoplasms

KW - polymerase chain reaction

KW - polymorphism, restriction fragment length

KW - polymorphism, single nucleotide

KW - Genetic Polymorphism

KW - Methylentetrahydrofolat-Reduktase

KW - Potentially malignant oral diseases

KW-Taiwan

M3 - artillery

Serial number - 0250-7005

VL-38

SP-4021

EP-4026

JO - Cancer Research

JF - Cancer Research

ES-7

ES -